769965-95-9Relevant academic research and scientific papers
A convenient cyclopropanation process of oxindoles via bromoethylsulfonium salt
Qin, Hui,Miao, Yuanyuan,Zhang, Ke,Xu, Jian,Sun, Haopeng,Liu, Wenyuan,Feng, Feng,Qu, Wei
, p. 6809 - 6814 (2018/10/20)
A practical convenient conversion of oxindoles into the corresponding spirocyclopropyl oxindoles is achieved efficiently using bromoethylsulfonium salt, which is easily prepared on a large scale and is stable crystalline. This reaction of bromoethylsulfonium salt with different substituted unprotected oxindoles proceeded under mild condition and provided moderate yields.
Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility
Zhou, Mingwei,En, Ke,Hu, Yimin,Xu, Yufang,Shen, Hong C.,Qian, Xuhong
, p. 3741 - 3745 (2017/02/05)
The first use of zinc triflate for the cyclopropanation of unprotected oxindoles with vinyl diphenyl sulfonium triflate salt is reported. The reaction proceeded under ambient conditions and consistently provided high yields with broad functional group tolerability. The utility for the late-stage functionalization (LSF) of complex molecules is demonstrated.
CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS
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Page/Page column 85, (2016/02/02)
There are described cydohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Tully, David C.,Liu, Hong,Chatterjee, Arnab K.,Alper, Phil B.,Williams, Jennifer A.,Roberts, Michael J.,Mutnick, Daniel,Woodmansee, David H.,Hollenbeck, Thomas,Gordon, Perry,Chang, Jonathan,Tuntland, Tove,Tumanut, Christine,Li, Jun,Harris, Jennifer L.,Karanewsky, Donald S.
, p. 5107 - 5111 (2007/10/03)
We report a novel series of noncovalent inhibitors of cathepsin S. The synthesis of the peptidomimetic scaffold is described and structure-activity relationships of P3, P1, and P1′ subunits are discussed. Lead optimization to a non-peptidic scaffold has r
INHIBITORS OF CATHEPSIN S
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, (2008/06/13)
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
INHIBITORS OF CATHEPSIN S
-
, (2008/06/13)
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
