4-bromo-3-trimethylsilylbenzonitrile

Base Information

• Chemical Name: 4-bromo-3-trimethylsilylbenzonitrile
• CAS No.: 1375579-27-3
• Molecular Formula: C₁₀H₁₂BrNSi
• Molecular Weight: 254.201
• Mol file: 1375579-27-3.mol

Synonyms:4-bromo-3-trimethylsilylbenzonitrile

Chemical Property of 4-bromo-3-trimethylsilylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-bromo-3-trimethylsilylbenzonitrile

There total 1 articles about 4-bromo-3-trimethylsilylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + 4-bromobenzenecarbonitrile (623-00-7) → 4-bromo-2-(trimethylsilyl)benzonitrile (1057732-31-6) + 4-bromo-3-trimethylsilylbenzonitrile (1375579-27-3)

Guidance literature:

4-bromobenzenecarbonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201108154

Reference yield: 80.0%

4-bromo-3-trimethylsilylbenzonitrile (1375579-27-3) + diphenyl acetylene (501-65-5) → C23H19NSi (1374337-14-0)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); tri-tert-butylphosphine; 4-nitrobenzaldehdye; lithium tert-butoxide; In toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201108154

upstream raw materials:

chloro-trimethyl-silane

4-bromobenzenecarbonitrile

Downstream raw materials:

C₂₃H₁₉NSi