2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• CAS No.: 101858-69-9
• Molecular Formula: C₂₁H₂₃NO₇S
• Molecular Weight: 433.482
• Mol file: 101858-69-9.mol

Synonyms:2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Chemical Property of 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

There total 6 articles about 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}isoindole-1,3-dione (75001-08-0) + p-toluenesulfonyl chloride (98-59-9) → 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate (101858-69-9)

Guidance literature:

With trimethylamine hydrochloride; triethylamine; In acetonitrile; at 0 - 25 ℃; for 1h;

DOI:10.1039/b518061a

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate (101858-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 16 h / 100 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With triethylamine; In dichloromethane; toluene;

Reference yield:

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) → 2-[2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate (101858-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / dimethylformamide / 18 h / 110 °C

2: 61 percent / pyridine / 18 h / 20 °C

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1039/b615873k

upstream raw materials:

2-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}isoindole-1,3-dione

p-toluenesulfonyl chloride

2-[2-(chloroethoxy)ethoxy]ethanol

potassium phtalimide

Downstream raw materials:

2-{2-[2-(2-{4-[(2-{2-[2-(4-methylbenzenesulfonyl)ethoxy]ethoxy}ethoxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethyl}isoindoline-1,3-dione

C₄₈H₆₈N₁₀O₁₆S

2-[2-(2-{2-[4-({2-[2-(2-{4-[(2-{2-[2-(4-methylbenzenesulfonyl)ethoxy]ethoxy}ethoxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}methyl)-1H-1,2,3-triazol-1-yl]ethoxy}ethoxy)ethyl]isoindoline-1,3-dione