4-(Trimethylsilyl)-1h-indole

Base Information

• Chemical Name: 4-(Trimethylsilyl)-1h-indole
• CAS No.: 82645-11-2
• Molecular Formula: C₁₁H₁₅NSi
• Molecular Weight: 189.332
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50413661
• Wikidata: Q82221944
• Mol file: 82645-11-2.mol

Synonyms:4-(Trimethylsilyl)-1h-indole;82645-11-2;1H-indol-4-yl(trimethyl)silane;4-trimethylsilylindole;4-(Trimethylsilyl)-1-H-Indole;DTXSID50413661;MFCD08436021;AKOS006345988;4-(TRIMETHYLSILYL)-1H-INDOLE98;BS-23182;4-(TRIMETHYLSILYL)-1H-INDOLE 98;CS-0456034;FT-0659727;A840402

Chemical Property of 4-(Trimethylsilyl)-1h-indole

Chemical Property:

• Vapor Pressure: 0.00228mmHg at 25°C
• Melting Point: 58-60
• Refractive Index: 1.558
• Boiling Point: 298.2 °C at 760 mmHg
• Flash Point: 134.2 °C
• PSA: 15.79000
• Density: 1 g/cm³
• LogP: 2.71310
• Storage Temp.: Keep Cold
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 189.097376017
• Heavy Atom Count: 13
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

4-(Trimethylsilyl)-1H-indole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C1=CC=CC2=C1C=CN2

Technology Process of 4-(Trimethylsilyl)-1h-indole

There total 7 articles about 4-(Trimethylsilyl)-1h-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-bis(trimethylsilyl)indole (83188-11-8) → 4-(Trimethylsilyl)indole (82645-11-2)

Guidance literature:

In methanol; Heating;

DOI:10.1039/c39820000636

Reference yield: 74.0%

4-bromo-1H-indole (52488-36-5) + chloro-trimethyl-silane (75-77-4) → 4-(Trimethylsilyl)indole (82645-11-2)

Guidance literature:

4-bromo-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

Reference yield:

indole (120-72-9) → 4-(Trimethylsilyl)indole (82645-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)n-BuLi / 1.) THF, -20 deg C, 1 h; 2.) YHF, -20 deg C, 1 h

With n-butyllithium;

DOI:10.1016/S0040-4020(01)86105-6

upstream raw materials:

chloro-trimethyl-silane

1-(triisopropylsilyl)-1H-indole

1,4-bis(trimethylsilyl)indole

indole

Downstream raw materials:

1-Acetyl-6-chloroacetylindole