methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

Base Information

Chemical Name:methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate
CAS No.:1374298-89-1
Molecular Formula:C₁₉H₁₄Cl₂N₄O₃
Molecular Weight:417.251
Hs Code.:

Synonyms:methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

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Chemical Property of methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

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Technology Process of methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

There total 7 articles about methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374298-88-0
methyl 7-amino-2-[(2,6-dichlorophenyl)amino]-6-hydroxy-1H-benzimidazole-5-carboxylate

: 63190-44-3
cyclopropanecarboximidic Acid Ethyl Ester Hydrochloride

: 1374298-89-1
methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

Guidance literature:: In dichloromethane; at 0 - 26 ℃; for 25h; Inert atmosphere;

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1374298-89-1
methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid; nitric acid / water / 14 h / 0 - 5 °C

2.1: sulfuric acid / ethanol / 24 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0 - 26 °C

4.1: sodium methylate / methanol; water / 0 - 26 °C

5.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

6.1: hydrogenchloride; iron / methanol; water / 2 h / Reflux

7.1: acetonitrile / 24 h / 22 - 26 °C

7.2: 22 - 26 °C

8.1: sulfuric acid; potassium nitrate / water / 0.5 h / 10 - 15 °C

9.1: iron; acetic acid / benzene / 3 h / Reflux

10.1: dichloromethane / 25 h / 0 - 26 °C / Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; sulfuric acid; nitric acid; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; sulfuric acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; benzene;

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 1374298-89-1
methyl 2-cyclopropyl-7-[(2,6-dichlorophenyl)amino]-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / ethanol / 24 h / Reflux

2.1: triethylamine / tetrahydrofuran / 0 - 26 °C

3.1: sodium methylate / methanol; water / 0 - 26 °C

4.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

5.1: hydrogenchloride; iron / methanol; water / 2 h / Reflux

6.1: acetonitrile / 24 h / 22 - 26 °C

6.2: 22 - 26 °C

7.1: sulfuric acid; potassium nitrate / water / 0.5 h / 10 - 15 °C

8.1: iron; acetic acid / benzene / 3 h / Reflux

9.1: dichloromethane / 25 h / 0 - 26 °C / Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; sulfuric acid; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; sulfuric acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; benzene;