2-Amino-4,5-dichlorobenzoic acid

Base Information

• Chemical Name: 2-Amino-4,5-dichlorobenzoic acid
• CAS No.: 20776-61-8
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Hs Code.: 2922499990
• European Community (EC) Number: 826-213-6
• Nikkaji Number: J83.025I
• Mol file: 20776-61-8.mol

Synonyms:2-AMINO-4,5-DICHLOROBENZOIC ACID;20776-61-8;Benzoic acid, 2-amino-4,5-dichloro-;2-AMINO-4,5-DICHLORO-BENZOIc acid;2-Aimo-4,5-dichlorobenzoic acid;2-AMINO-4,5-DICHLOROBENZOICACID;2-AMINO-4 pound not5-DICHLOROBENZOIC ACID;SCHEMBL3031603;MQWFRBVVABTUKS-UHFFFAOYSA-N;CL8019;MFCD08457795;AKOS000282637;AM82970;SB35231;AS-45987;BB 0261445;FT-0611079;A20126;EN300-142558;Z1269194034

Chemical Property of 2-Amino-4,5-dichlorobenzoic acid

Chemical Property:

• Appearance/Colour: slight yellow crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 213-214℃
• Refractive Index: 1.658
• Boiling Point: 380.503 °C at 760 mmHg
• PKA: 4.34±0.10(Predicted)
• Flash Point: 183.922 °C
• PSA: 63.32000
• Density: 1.608g/cm³
• LogP: 2.85500
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 204.9697338
• Heavy Atom Count: 12
• Complexity: 188

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4,5-dichlorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1Cl)Cl)N)C(=O)O

Technology Process of 2-Amino-4,5-dichlorobenzoic acid

There total 13 articles about 2-Amino-4,5-dichlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-amino-4,5-dichloro-benzoic acid methyl ester (844647-17-2) → 2-amino-4,5-dichloro-benzoic acid (20776-61-8)

Guidance literature:

With lithium hydrochloride monohydrate; In methanol; water; at 20 ℃;

Reference yield:

2,4,5-trichlorobenzoic acid (50-82-8) → 2-amino-4,5-dichloro-benzoic acid (20776-61-8)

Guidance literature:

With ammonia; copper; at 135 - 140 ℃;

Reference yield:

2,4,5-trichlorobenzoic acid (50-82-8) + ammonia (7664-41-7) → 2-amino-4,5-dichloro-benzoic acid (20776-61-8)

Guidance literature:

at 135 - 140 ℃;

upstream raw materials:

5,6-dichloroisatin

2,4,5-trichlorobenzoic acid

5,6-dichloro-2-hydroxyisoindoline-1,3-dione

ammonia

Downstream raw materials:

6,7-dichloroquinazolin-4(3H)-one

2-(carboxymethyl-amino)-4,5-dichloro-benzoic acid

2-Amino-4,5-dichloro-benzoic acid hydrazide

methyl (2S)-{[(2-amino-4,5-dichlorophenyl)carbonyl]amino}(cyclohexyl)-ethanoate

Refernces

• 1、 Zhang, Lei,Chen, Xiaojie,Liu, Jun,Zhu, Qingzhang,Leng, Ying,Luo, Xiaomin,Jiang, Hualiang,Liu, Hong. "Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase". . p. 624 - 639. Retrieved 2013/02/21.
• 2、 -. "SULFONAMIDE COMPOUNDS". Page/Page column 19. . Retrieved 2010/10/20.