Technology Process of C19H16FN3O2
There total 6 articles about C19H16FN3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-ol;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
2-fluoroethyl bromide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2012.05.069
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / isopropyl alcohol / Reflux
2.1: water; sodium hydroxide / methanol
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
3.2: 4 h / 60 °C / Inert atmosphere
With
pyridine; water; potassium carbonate; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.05.069
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: nitric acid; acetic acid / 0 - 5 °C
2.1: palladium on activated charcoal; hydrogen
3.1: 160 - 170 °C
4.1: methanesulfonic acid; L-methionine / 120 °C
5.1: pyridine; dmap / 100 °C
6.1: trichlorophosphate / toluene / Reflux
7.1: pyridine / isopropyl alcohol / Reflux
8.1: water; sodium hydroxide / methanol
9.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
9.2: 4 h / 60 °C / Inert atmosphere
With
pyridine; dmap; methanesulfonic acid; L-methionine; palladium on activated charcoal; water; hydrogen; nitric acid; potassium carbonate; acetic acid; sodium hydroxide; trichlorophosphate;
In
methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2012.05.069