2-FLUORO-6-IODOANISOLE

Base Information

• Chemical Name: 2-FLUORO-6-IODOANISOLE
• CAS No.: 32750-21-3
• Molecular Formula: C7H6FIO
• Molecular Weight: 252.027
• Hs Code.: 2909309090
• Mol file: 32750-21-3.mol

Synonyms:Anisole,2-fluoro-6-iodo- (8CI);

Chemical Property of 2-FLUORO-6-IODOANISOLE

Chemical Property:

• Vapor Pressure: 0.061mmHg at 25°C
• Melting Point: 50 °C
• Refractive Index: 1.57
• Boiling Point: 239.645 °C at 760 mmHg
• Flash Point: 98.734 °C
• PSA: 9.23000
• Density: 1.804 g/cm³
• LogP: 2.43890
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-6-iodoanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-6-IODOANISOLE

There total 3 articles about 2-FLUORO-6-IODOANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-6-iodophenylboronic acid (870777-22-3) → 1-fluoro-3-iodo-2-methoxybenzene (32750-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃; t-BuOOH / H₂O / 20 - 25 °C

2: 30.5 g / NaOH / H₂O

With tert.-butylhydroperoxide; sodium hydroxide; potassium carbonate; In water;

DOI:10.1016/j.tet.2005.04.051

Reference yield:

2-fluoro-6-iodophenol (28177-50-6) + dimethyl sulfate (77-78-1) → 1-fluoro-3-iodo-2-methoxybenzene (32750-21-3)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1016/j.tet.2005.04.051

Reference yield:

3-fluoro-2-methoxyaniline (437-83-2) → 1-fluoro-3-iodo-2-methoxybenzene (32750-21-3)

Guidance literature:

Multistep reaction; (i) aq. HCl, NaNO₂, (ii) KI;

upstream raw materials:

3-fluoro-2-methoxyaniline

2-fluoro-6-iodophenol

dimethyl sulfate

2-fluoro-6-iodophenylboronic acid

Downstream raw materials:

2-fluoro-3,6-diiodoanisole

Refernces