toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester
CAS No.:846543-17-7
Molecular Formula:C₂₆H₂₈O₅S
Molecular Weight:452.571
Hs Code.:

Synonyms:toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Suppliers and Price of toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

There total 7 articles about toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98-59-9
p-toluenesulfonyl chloride

: 846543-16-6
4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenol

: 846543-17-7
toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 498-00-0
4-hydroxymethyl-2-methoxyphenol

: 846543-17-7
toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / tosyl acid / 20 °C

2.1: BuLi / tetrahydrofuran / -15 - 0 °C

2.2: tetrahydrofuran / -10 °C

3.1: DDQ / CH₂Cl₂; H₂O / 20 °C

4.1: K₂CO₃ / acetone / Heating

4.2: 81 percent / 185 °C

5.1: 93 percent / K₂CO₃ / acetone / Heating

6.1: m-CPBA / CH₂Cl₂ / 0 °C

6.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

7.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

With n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; acetone; 4.2: Claisen rearrangement / 6.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 18102-32-4
4-hydroxy-3-methoxy-2-methylbenzaldehyde

: 846543-17-7
toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-allyl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / acetone / Heating

1.2: 81 percent / 185 °C

2.1: 93 percent / K₂CO₃ / acetone / Heating

3.1: m-CPBA / CH₂Cl₂ / 0 °C

3.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

4.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone; 1.2: Claisen rearrangement / 3.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148