6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Base Information

Chemical Name:6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester
CAS No.:846543-19-9
Molecular Formula:C₃₂H₃₈O₈S
Molecular Weight:582.715
Hs Code.:

Synonyms:6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Suppliers and Price of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

There total 10 articles about 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 74-88-4
methyl iodide

: 856190-62-0
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

: 846543-19-9
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone; Heating;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 498-00-0
4-hydroxymethyl-2-methoxyphenol

: 846543-19-9
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / tosyl acid / 20 °C

2.1: BuLi / tetrahydrofuran / -15 - 0 °C

2.2: tetrahydrofuran / -10 °C

3.1: DDQ / CH₂Cl₂; H₂O / 20 °C

4.1: K₂CO₃ / acetone / Heating

4.2: 81 percent / 185 °C

5.1: 93 percent / K₂CO₃ / acetone / Heating

6.1: m-CPBA / CH₂Cl₂ / 0 °C

6.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

7.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

8.1: 90 percent / Billig ligand; H₂; Rh(CO)2(acac) / toluene / 60 °C

9.1: 87 percent / SnCl₂ / CH₂Cl₂ / 20 °C

10.1: 93 percent / K₂CO₃ / acetone / Heating

With acetylacetonatodicarbonylrhodium(l); n-butyllithium; Billig ligand; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water; acetone; toluene; 4.2: Claisen rearrangement / 6.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 18102-32-4
4-hydroxy-3-methoxy-2-methylbenzaldehyde

: 846543-19-9
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-2-methyl-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: K₂CO₃ / acetone / Heating

1.2: 81 percent / 185 °C

2.1: 93 percent / K₂CO₃ / acetone / Heating

3.1: m-CPBA / CH₂Cl₂ / 0 °C

3.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

4.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

5.1: 90 percent / Billig ligand; H₂; Rh(CO)2(acac) / toluene / 60 °C

6.1: 87 percent / SnCl₂ / CH₂Cl₂ / 20 °C

7.1: 93 percent / K₂CO₃ / acetone / Heating

With acetylacetonatodicarbonylrhodium(l); Billig ligand; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; In dichloromethane; acetone; toluene; 1.2: Claisen rearrangement / 3.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148