6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Base Information

Chemical Name:6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester
CAS No.:856190-62-0
Molecular Formula:C₃₁H₃₆O₈S
Molecular Weight:568.688
Hs Code.:

Synonyms:6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Suppliers and Price of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

There total 9 articles about 6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 623-73-4
diazoacetic acid ethyl ester

: 846543-18-8
toluene-4-sulfonic acid 4-benzyloxy-3-methoxy-2-methyl-5-(1-methyl-4-oxo-butyl)-phenyl ester

: 856190-62-0
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Guidance literature:: With tin(ll) chloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 498-00-0
4-hydroxymethyl-2-methoxyphenol

: 856190-62-0
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 100 percent / tosyl acid / 20 °C

2.1: BuLi / tetrahydrofuran / -15 - 0 °C

2.2: tetrahydrofuran / -10 °C

3.1: DDQ / CH₂Cl₂; H₂O / 20 °C

4.1: K₂CO₃ / acetone / Heating

4.2: 81 percent / 185 °C

5.1: 93 percent / K₂CO₃ / acetone / Heating

6.1: m-CPBA / CH₂Cl₂ / 0 °C

6.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

7.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

8.1: 90 percent / Billig ligand; H₂; Rh(CO)2(acac) / toluene / 60 °C

9.1: 87 percent / SnCl₂ / CH₂Cl₂ / 20 °C

With acetylacetonatodicarbonylrhodium(l); n-butyllithium; Billig ligand; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tin(ll) chloride; In tetrahydrofuran; dichloromethane; water; acetone; toluene; 4.2: Claisen rearrangement / 6.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148

Reference yield:

: 18102-32-4
4-hydroxy-3-methoxy-2-methylbenzaldehyde

: 856190-62-0
6-[2-benzyloxy-3-methoxy-4-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-3-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃ / acetone / Heating

1.2: 81 percent / 185 °C

2.1: 93 percent / K₂CO₃ / acetone / Heating

3.1: m-CPBA / CH₂Cl₂ / 0 °C

3.2: 61 percent / Et₃N / CH₂Cl₂; methanol / 20 °C

4.1: 88 percent / Et₃N / CH₂Cl₂ / 20 °C

5.1: 90 percent / Billig ligand; H₂; Rh(CO)2(acac) / toluene / 60 °C

6.1: 87 percent / SnCl₂ / CH₂Cl₂ / 20 °C

With acetylacetonatodicarbonylrhodium(l); Billig ligand; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; In dichloromethane; acetone; toluene; 1.2: Claisen rearrangement / 3.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tetlet.2004.11.148