N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

Base Information

Chemical Name:N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide
CAS No.:1419183-40-6
Molecular Formula:C₅₆H₆₈FN₃O₉S
Molecular Weight:978.235
Hs Code.:

N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

Synonyms:N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

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Chemical Property of N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

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Technology Process of N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

There total 9 articles about N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1337864-02-4
2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

: 1419183-39-3
N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-1-fluorocyclo-oct-2-ynecarboxamide

: 1419183-40-6
N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: (3-iodo-4-methoxyphenyl)bis(4-methoxyphenyl)methanol

: 1419183-40-6
N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C

4: triethylamine / dichloromethane / 12 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

: 1419183-40-6
N-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-1-fluorocyclooct-2-ynecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C

3: triethylamine / dichloromethane / 12 h / 20 °C

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane;