2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

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Chemical Name:2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate
CAS No.:1337864-02-4
Molecular Formula:C₄₁H₄₀N₂O₈S
Molecular Weight:720.843
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

There total 5 articles about 2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1337864-05-7
3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

: 1337864-02-4
2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c1cc11814e

Reference yield:

: 845272-53-9
(3-iodo-4-methoxyphenyl)(4-methoxyphenyl)methanone

: 1337864-02-4
2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Grignard reaction / 2: Sonogashira coupling;
DOI:10.1039/c1cc11814e

Reference yield:

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

: 1337864-02-4
2,5-dioxopyrrolidin-1-yl 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}bis{4-methoxyphenyl}methyl)thio]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c1cc11814e