N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

Base Information

Chemical Name:N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide
CAS No.:1337864-04-6
Molecular Formula:C₃₄H₃₃NO₅
Molecular Weight:535.64
Hs Code.:

Synonyms:N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

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Chemical Property of N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

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Technology Process of N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

There total 3 articles about N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (3-iodo-4-methoxyphenyl)bis(4-methoxyphenyl)methanol

: 112404-94-1
N-benzyl-4-pentynoic acid amide

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1039/c1cc11814e

Reference yield:

: 90-96-0
bis(p-methoxyphenyl)methanone

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; nitric acid / water / 7 h / 60 °C

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Grignard reaction / 3: Sonogashira coupling;
DOI:10.1039/c1cc11814e

Reference yield:

: 845272-53-9
(3-iodo-4-methoxyphenyl)(4-methoxyphenyl)methanone

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Grignard reaction / 2: Sonogashira coupling;
DOI:10.1039/c1cc11814e