3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

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Chemical Name:3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid
CAS No.:1337864-05-7
Molecular Formula:C₃₇H₃₇NO₆S
Molecular Weight:623.77
Hs Code.:

Synonyms:3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

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Chemical Property of 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

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Technology Process of 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

There total 4 articles about 3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1337864-04-6
N-benzyl-3-{2-methoxy-5-[hydroxyl-bis(4-methoxyphenyl)methyl]phenyl}-4-pentynoic amide

: 107-96-0
3-mercaptopropionic acid

: 1337864-05-7
3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c1cc11814e

Reference yield:

: 90-96-0
bis(p-methoxyphenyl)methanone

: 1337864-05-7
3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; nitric acid / water / 7 h / 60 °C

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: Grignard reaction / 3: Sonogashira coupling;
DOI:10.1039/c1cc11814e

Reference yield:

: 845272-53-9
(3-iodo-4-methoxyphenyl)(4-methoxyphenyl)methanone

: 1337864-05-7
3-[({3-[5-(benzylamino)-5-oxopent-1-yn-1-yl]-4-methoxyphenyl}-bis{4-methoxyphenyl}methyl)thio]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Grignard reaction / 2: Sonogashira coupling;
DOI:10.1039/c1cc11814e