2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

Base Information

Chemical Name:2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane
CAS No.:925545-50-2
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0<sup>3,7</sup>]dodecane

Synonyms:2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

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Chemical Property of 2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

Chemical Property:

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Technology Process of 2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

There total 8 articles about 2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 925545-70-6
5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecan-2-ol

: 100-39-0
benzyl bromide

: 925545-50-2
2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol062621o

Reference yield:

: (5-allyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-benzyloxy-acetaldehyde

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 925545-50-2
2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; Heating;
DOI:10.1021/ol062621o

Reference yield:

: 912642-25-2
oct-7-ene-1,2,3,4,5-pentaol

: 925545-50-2
2-benzyloxy-5,5,11-trimethyl-4,6,10-trioxa-11-aza-tricyclo[7.2.1.0^3,7]dodecane

Guidance literature:: Multi-step reaction with 5 steps

1: 264 mg / anhydrous CuSO₄ / 24 h / 20 °C

2: 97 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 0 - 20 °C

3: 87 percent Turnov_. / AcOH / H₂O / 9 h / 20 °C

4: NaIO₄; silica gel / H₂O; CH₂Cl₂ / 20 - 80 °C

5: 366 mg / NaHCO₃ / acetonitrile / Heating

With sodium periodate; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; copper(II) sulfate; acetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ol062621o