2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine
CAS No.:1357143-02-2
Molecular Formula:C₂₄H₃₄BN₃O₄Si
Molecular Weight:467.448
Hs Code.:

Synonyms:2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

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Chemical Property of 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

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Technology Process of 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

There total 5 articles about 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357143-01-1
2-(4-bromophenoxy)-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

: 73183-34-3
bis(pinacol)diborane

: 1357143-02-2
2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

Reference yield:

: 63277-46-3
2-(methylthio)imidazo<4,5-c>pyridine hydrochloride

: 1357143-02-2
2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 4 h / 0 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

3: triethylamine / 6 h / 120 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide; tetrahydrofuran / 80 °C / Inert atmosphere

With potassium acetate; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 29448-81-5
2-mercapto-1H-imidazo[4,5-b]pyridine

: 1357143-02-2
2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 24 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 4 h / 0 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

4: triethylamine / 6 h / 120 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide; tetrahydrofuran / 80 °C / Inert atmosphere

With potassium acetate; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;