1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

Base Information

Chemical Name:1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide
CAS No.:1396772-75-0
Molecular Formula:C₃₁H₃₇N₅O₃
Molecular Weight:527.666
Hs Code.:

Synonyms:1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

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Chemical Property of 1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

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Technology Process of 1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

There total 11 articles about 1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.9%

: 1396780-52-1
1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-hydroxypropoxy)phenyl)-1H-indazole-4-carboxamide

: 74-89-5
methylamine

: 1396772-75-0
1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: 1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-hydroxypropoxy)phenyl)-1H-indazole-4-carboxamide; With triphenylphosphine; In dichloromethane; at 20 ℃; for 0.166667h;

With carbon tetrabromide; In dichloromethane; at 20 ℃; for 4h;

methylamine; In tetrahydrofuran; dichloromethane; at 20 - 60 ℃; for 30h;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1396772-75-0
1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

4.1: potassium acetate / chloroform / 12 h / 20 °C

4.2: 3 h / 65 °C

5.1: hydrogenchloride / water; methanol / 8 h / 60 °C

5.2: pH 8

6.1: caesium carbonate / acetonitrile / 90 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / Inert atmosphere

7.2: 2.17 h / 80 °C / Inert atmosphere

8.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

9.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

9.2: pH 6

10.1: dimethyl sulfoxide / 0.25 h / 20 °C

11.1: triphenylphosphine / dichloromethane / 0.17 h / 20 °C

11.2: 4 h / 20 °C

11.3: 30 h / 20 - 60 °C

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; potassium acetate; iron; sodium carbonate; potassium carbonate; ammonium chloride; caesium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1396772-75-0
1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: potassium acetate / chloroform / 12 h / 20 °C

3.2: 3 h / 65 °C

4.1: hydrogenchloride / water; methanol / 8 h / 60 °C

4.2: pH 8

5.1: caesium carbonate / acetonitrile / 90 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / Inert atmosphere

6.2: 2.17 h / 80 °C / Inert atmosphere

7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

8.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

8.2: pH 6

9.1: dimethyl sulfoxide / 0.25 h / 20 °C

10.1: triphenylphosphine / dichloromethane / 0.17 h / 20 °C

10.2: 4 h / 20 °C

10.3: 30 h / 20 - 60 °C

With hydrogenchloride; water; potassium acetate; iron; sodium carbonate; potassium carbonate; ammonium chloride; caesium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;