C₂₁H₂₃NO₂

Base Information

• Chemical Name: C₂₁H₂₃NO₂
• CAS No.: 1531590-64-3
• Molecular Formula: C₂₁H₂₃NO₂
• Molecular Weight: 321.419
• Mol file: 1531590-64-3.mol

Synonyms:C₂₁H₂₃NO₂

Chemical Property of C₂₁H₂₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃NO₂

There total 1 articles about C₂₁H₂₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hex-5-ynoic acid (53293-00-8) + (1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol (550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4) → C21H23NO2 (1531590-64-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201309449

Reference yield: 78.0%

2-iodo-propane (75-30-9) + C21H23NO2 (1531590-64-3) → C24H29NO2 (1531590-65-4)

Guidance literature:

C₂₁H₂₃NO₂; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

2-iodo-propane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201309449

Reference yield:

C21H23NO2 (1531590-64-3) → C22H29NO6 (1531590-72-3) + C22H29NO6 (1531590-73-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetra(n-butyl)ammonium hydroxide / tert-butyl alcohol; water / 36 h / 20 - 100 °C / Inert atmosphere

2.2: pH <= 1 / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 20.5 h / 20 °C / Inert atmosphere

5.1: S-alpine borane / tetrahydrofuran / 11 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

7.1: N,N,N,N,N,N-hexamethylphosphoric triamide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; indium iodide / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere

8.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

9.1: potassium carbonate / ethanol / 2 h / 20 °C / Inert atmosphere

10.1: 4-nitro-benzoic acid; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; silver hexafluoroantimonate / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; silver hexafluoroantimonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; indium iodide; di-isopropyl azodicarboxylate; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; S-alpine borane; tetra(n-butyl)ammonium hydroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; lithium diisopropyl amide; 4-nitro-benzoic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1002/anie.201309449

upstream raw materials:

hex-5-ynoic acid

(1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol

Downstream raw materials:

C₂₂H₂₉NO₆

C₂₂H₂₉NO₆

(1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol

C₂₄H₂₉NO₂