(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

Base Information

Chemical Name:(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate
CAS No.:479482-39-8
Molecular Formula:C₃₃H₄₄O₇
Molecular Weight:552.708
Hs Code.:

(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

Synonyms:(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

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Chemical Property of (2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

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Technology Process of (2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

There total 3 articles about (2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 107-21-1
ethylene glycol

: 81189-93-7
(2R,4R)-2-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-6-oxo-2H-pyran-4-yl benzoate

: 479482-39-8
(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

Guidance literature:: With sulfuric acid; orthoformic acid triethyl ester; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1002/hlca.200390066

Reference yield:

: 98-88-4
benzoyl chloride

: 479482-39-8
(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / pyridine / toluene / 18 h / 20 °C

2: 51 percent / (EtO)3CH; H₂SO₄ / tetrahydrofuran / 48 h / 20 °C

With pyridine; sulfuric acid; orthoformic acid triethyl ester; In tetrahydrofuran; toluene;
DOI:10.1002/hlca.200390066

Reference yield:

: 75330-75-5,79952-44-6
lovastatin

: 479482-39-8
(2R,4R)-2,2-(ethylenedioxy)-6-[2-((1S,2S,6R,8S,8aR)-1,2,3,7,8,8a-hexahydro-2,6-dimethyl-8-{[(S)-2-methylbutanoyl]oxy}naphthalen-1-yl)ethyl]-3,4,5,6-tetrahydro-2H-pyran-4-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / pyridine / toluene / 18 h / 20 °C

2: 51 percent / (EtO)3CH; H₂SO₄ / tetrahydrofuran / 48 h / 20 °C

With pyridine; sulfuric acid; orthoformic acid triethyl ester; In tetrahydrofuran; toluene;
DOI:10.1002/hlca.200390066