1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester
• CAS No.: 426842-70-8
• Molecular Formula: C14H23 N O4
• Molecular Weight: 269.341
• Mol file: 426842-70-8.mol

Synonyms:1,4-Piperidinedicarboxylicacid, 4-(2-propenyl)-, 1-(1,1-dimethylethyl) ester (9CI);4-Allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;4-Allyl-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

Chemical Property:

• Boiling Point: 380.3±35.0 °C(Predicted)
• PKA: 4.55±0.20(Predicted)
• PSA: 66.84000
• Density: 1.101±0.06 g/cm3(Predicted)
• LogP: 2.60230

Purity/Quality:

97% ^*data from raw suppliers

4-Allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

There total 5 articles about 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate (441774-09-0) → 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (426842-70-8)

Guidance literature:

With water; potassium hydroxide; In tetrahydrofuran; methanol; at 65 ℃; for 5.5h;

DOI:10.1055/s-0030-1260188

Reference yield: 49.0%

allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate (676341-47-2) → 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (426842-70-8)

Guidance literature:

allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With hydrogenchloride; more than 3 stages;

Reference yield:

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate (146603-99-8) → 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (426842-70-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; water;

upstream raw materials:

1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate

allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate

Downstream raw materials:

4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine

1-tert-butoxycarbonyl-4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)piperidine

4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine

3-[4-allyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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