5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

Base Information

Chemical Name:5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine
CAS No.:1349723-33-6
Molecular Formula:C₁₈H₁₄Cl₂FN₅O
Molecular Weight:406.246
Hs Code.:

Synonyms:5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

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Chemical Property of 5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

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Technology Process of 5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

There total 7 articles about 5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 178813-77-9
2,6-dichloro-3-fluorobenzaldehyde

: 1349723-36-9
3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

: 1349723-33-6
5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

Guidance literature:: With potassium hydroxide; at 110 ℃; Sealed tube;

Reference yield:

: 1207625-18-0
3-chloro-7H-pyrrolo[2,3-c]pyridazine

: 1349723-33-6
5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 13 h / 100 °C / Inert atmosphere

2: potassium hydroxide / 110 °C / Sealed tube

With caesium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;

Reference yield:

: 1207625-15-7
6-chloro-4-((trimethylsilyl)ethynyl)pyridazin-3-amine

: 1349723-33-6
5-[(2,6-dichloro-3-fluorophenyl)(methoxy)methyl]-3-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.01 h / 190 °C / Sealed tube; Microwave irradiation

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 13 h / 100 °C / Inert atmosphere

3: potassium hydroxide / 110 °C / Sealed tube

With copper(l) iodide; caesium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;