1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

Base Information

Chemical Name:1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine
CAS No.:1352721-53-9
Molecular Formula:C₂₇H₂₅ClN₆O₂
Molecular Weight:500.988
Hs Code.:

Synonyms:1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

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Chemical Property of 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

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Technology Process of 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

There total 9 articles about 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1352721-54-0
1-(1H-indol-4-ylmethyl)-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1352721-53-9
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 1352721-53-9
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / acetonitrile / 16 h

1.2: 16 h

2.1: diisobutylaluminium hydride / cyclohexane; tetrahydrofuran / 16.33 h / -78 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C

3.2: 1.17 h / 0 °C

4.1: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

5.1: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With carbon tetrabromide; water; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium iodide; dmap; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 87120-73-8
tert‐butyl 4‐((2‐nitrophenyl)amino)piperidine‐1‐carboxylate

: 1352721-53-9
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 760.05 Torr

2: water / acetonitrile / 22 h / 20 °C

3: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

4: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With water; hydrogen; caesium carbonate; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;