2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate

Base Information

• Chemical Name: 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate
• CAS No.: 1001077-57-1
• Molecular Formula: C₁₂H₁₄ClN₃O₄S
• Molecular Weight: 331.78

Synonyms:2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate

Chemical Property of 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate

There total 3 articles about 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(2-hydroxy-ethyl)-2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (501675-34-9) + methanesulfonyl chloride (124-63-0) → 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate (1001077-57-1)

Guidance literature:

With pyridine; at 20 ℃; for 15h;

DOI:10.1002/jhet.5570440620

Reference yield:

3-(4-chlorophenyl)sydnone (829-31-2) → 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate (1001077-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / 0 - 60 °C

2: 150 - 160 °C

3: triethylamine / 0 - 25 °C

With bromine; triethylamine;

DOI:10.1016/j.ejmech.2013.01.004

Reference yield:

3-(4-chlorophenyl)-5-methyl-2-oxo-Δ4-1,3,4-oxadiazole (269392-85-0) → 2-[2-(4-chlorophenyl)-5-methyl-3-oxo-2,4-dihydro-3H-1,2,4-triazol-4-yl]ethyl methanesulfonate (1001077-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 150 - 160 °C

2: triethylamine / 0 - 25 °C

With triethylamine;

DOI:10.1016/j.ejmech.2013.01.004

upstream raw materials:

4-(2-hydroxy-ethyl)-2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

methanesulfonyl chloride

3-(4-chlorophenyl)sydnone

3-(4-chlorophenyl)-5-methyl-2-oxo-Δ⁴-1,3,4-oxadiazole

Downstream raw materials:

2-(4-chlorophenyl)-4-(2-azidoethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

4-(2-(1H-1,2,4-triazol-1-yl)ethyl)-2-(4-chlorophenyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one

C₁₅H₁₉ClN₄O₂

4-(2-(1H-benzo[d][1,2,3]triazol-1-yl)ethyl)-2-(4-chlorophenyl)-5-methyl-2H-1,2,4-triazol-3(4H)-one

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