(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

Base Information

Chemical Name:(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one
CAS No.:1234387-30-4
Molecular Formula:C₁₈H₂₈BrNO₂Si
Molecular Weight:398.415
Hs Code.:

Synonyms:(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

Suppliers and Price of (R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

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Technology Process of (R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

There total 6 articles about (R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 405522-18-1
(R)-5-(4-bromophenyl)pyrrolidin-2-one

: 101166-65-8
2-tert-butyldimethylsilyloxyethyl iodide

: 1234387-30-4
(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Reflux;
DOI:10.1002/cjoc.201300363

Reference yield:

: 405522-29-4
(3S,7aS)-7a-(4-bromophenyl)-3-phenyltetrahydropyrrolo[2,1-b]oxazol-5(6H)-one

: 1234387-30-4
(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: titanium tetrachloride; triethylsilane / dichloromethane / 16 h / -78 °C

2: thionyl chloride / tetrahydrofuran / 2 h / 0 - 20 °C

3: sodium / ethanol / 4 h / 45 °C

4: hydrogenchloride / tetrahydrofuran; water / 3 h / Reflux

5: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Reflux

With hydrogenchloride; triethylsilane; thionyl chloride; sodium; titanium tetrachloride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201300363

Reference yield:

: 405522-31-8
(R)-5-(4-bromophenyl)-1-((S)-2-hydroxy-1-phenylethyl)pyrrolidin-2-one

: 1234387-30-4
(R)-5-(4-bromophenyl)-1-(2-(tert-butyldimethylsilyloxy)ethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / tetrahydrofuran / 2 h / 0 - 20 °C

2: sodium / ethanol / 4 h / 45 °C

3: hydrogenchloride / tetrahydrofuran; water / 3 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Reflux

With hydrogenchloride; thionyl chloride; sodium; sodium hydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201300363