2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid

Base Information

• Chemical Name: 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid
• CAS No.: 78235-49-1
• Molecular Formula: C₁₈H₁₄Cl₃NO₆
• Molecular Weight: 446.671

Synonyms:2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid

Chemical Property of 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid

Chemical Property:

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Technology Process of 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid

There total 2 articles about 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,3-dichloro-4-(4-nitrobenzoyl)phenoxyacetate (75554-04-0) → 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid (78235-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetaldoxime, NaOH / dimethylformamide / 18 h / Ambient temperature

2: CH₃SO₃H / 3 h / Ambient temperature

With sodium hydroxide; Acetaldehyde oxime; methanesulfonic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00378a010

Reference yield:

2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1) + 2,3-dichloro-4-(4'-hydroxybenzoyl)-phenoxyacetic acid (62967-00-4) → 2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid (78235-49-1)

Guidance literature:

With methanesulfonic acid; for 3h; Ambient temperature;

DOI:10.1021/jm00378a010

Reference yield:

2,3-dichloro-4-<3-<(2-chloroacetamido)methyl>-4-hydroxybenzoyl>phenoxyacetic acid (78235-49-1) → (2,3-Dichloro-4-{3-[(2-chloro-acetylamino)-methyl]-4-hydroxy-5-iodo-benzoyl}-phenoxy)-acetic acid (92270-40-1)

Guidance literature:

With Iodine monochloride; In acetic acid; at 75 ℃; for 20h;

DOI:10.1021/jm00378a010

upstream raw materials:

2-Chloro-N-(hydroxymethyl)acetamide

2,3-dichloro-4-(4'-hydroxybenzoyl)-phenoxyacetic acid

ethyl 2,3-dichloro-4-(4-nitrobenzoyl)phenoxyacetate

Downstream raw materials:

(2,3-Dichloro-4-{3-[(2-chloro-acetylamino)-methyl]-4-hydroxy-5-iodo-benzoyl}-phenoxy)-acetic acid

<2,3-dichloro-4-<3-(aminomethyl)-4-hydroxybenzoyl>phenoxy>acetic acid

ethyl {2,3-dichloro-4-[3-(aminomethyl)-4-hydroxybenzoyl]phenoxy}acetate

{4-[3-(Acetylamino-methyl)-4-hydroxy-benzoyl]-2,3-dichloro-phenoxy}-acetic acid ethyl ester

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