6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone

Base Information

• Chemical Name: 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone
• CAS No.: 525559-02-8
• Molecular Formula: C₁₆H₂₀N₂O₃S
• Molecular Weight: 320.412
• Mol file: 525559-02-8.mol

Synonyms:6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone

Chemical Property of 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone

There total 2 articles about 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

benzyl bromide (100-39-0) + ethyl 4,4-diethoxyacetoacetate (10495-09-7) + thiourea (17356-08-0) → 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone (525559-02-8)

Guidance literature:

ethyl 4,4-diethoxyacetoacetate; thiourea; With sodium methylate; In methanol; ethanol; for 16h; Reflux;

benzyl bromide; In methanol; ethanol; water;

Reference yield:

benzyl bromide (100-39-0) + Ethyl diethoxyacetate (6065-82-3) → 2-benzylsulfanyl-6-diethoxymethyl-pyrimidin-4-ol (525559-02-8)

Guidance literature:

With sodium methylate; thiourea; In ethanol; ethyl acetate;

Reference yield: 94.0%

6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone (525559-02-8) → 4-[bis(ethyloxy)methyl]-6-chloro-2-[(phenylmethyl)thio]pyrimidine (525559-14-2)

Guidance literature:

6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4(1H)-pyrimidinone; With N,N-dimethyl-formamide; trichlorophosphate; In toluene; for 2h; Inert atmosphere; Cooling with ice;

With sodium carbonate; In water; N,N-dimethyl-formamide;

upstream raw materials:

benzyl bromide

Ethyl diethoxyacetate

ethyl 4,4-diethoxyacetoacetate

thiourea

Downstream raw materials:

4-[bis(ethyloxy)methyl]-6-chloro-2-[(phenylmethyl)thio]pyrimidine

Refernces

• 1、 -. "Aminopyrimidine and aminopyridine anti-inflammation agents". . . Retrieved 2008/06/13.