Decitabine iMpurity 4

Base Information

• Chemical Name: Decitabine iMpurity 4
• CAS No.: 863396-35-4
• Molecular Formula: C₆H₁₂O₄
• Molecular Weight: 148.159
• Mol file: 863396-35-4.mol

Synonyms:methyl-2-deoxyribopyranoside

Chemical Property of Decitabine iMpurity 4

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-deoxy-D-erythro-pentopyranoside(DecitabineImpurity(Mixtureofα/βisomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-deoxy-D-erythro-pentopyranoside is an impurity of Decitabine (α-isomer: D226730), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, “normalizing” gene expression in cancerous cells.

Technology Process of Decitabine iMpurity 4

There total 7 articles about Decitabine iMpurity 4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 2-Deoxy-D-ribose (533-67-5) → methyl-2-deoxyribopyranoside (863396-35-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1055/s-2006-950401

Reference yield:

methanol (67-56-1) + 2-Deoxy-D-ribose (533-67-5) → methyl-2-deoxyribopyranoside (863396-35-4) + 1-O-methyl-2-deoxy-D-ribofuranoside (51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; Product distribution / selectivity;

Reference yield:

methanol (67-56-1) + 2-deoxy-D-ribose (22900-10-3,35536-75-5,36792-85-5,113890-34-9,113890-37-2,133813-23-7) → methyl-2-deoxyribopyranoside (863396-35-4) + 1-O-methyl-2-deoxy-D-ribofuranoside (51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9)

Guidance literature:

methanol; With acetyl chloride; at 20 ℃; Inert atmosphere;

2-deoxy-D-ribose; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.08.035

upstream raw materials:

methanol

2-deoxy-D-ribose

D-2-deoxyribose

2-Deoxy-D-ribose

Downstream raw materials:

C₂₀H₂₄O₈S₂

(7E,9E,11E,13E)-(5S,6R,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

lipoxin A₄

(4R,5S)-tetrahydro-2H-pyran-2,4,5-triol