3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem

Base Information

• Chemical Name: 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem
• CAS No.: 132645-19-3
• Molecular Formula: C₂₃H₂₁N₃O₇S
• Molecular Weight: 483.502
• Mol file: 132645-19-3.mol

Synonyms:3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem

Chemical Property of 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem

There total 1 articles about 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-((R)-2-Hydroxymethyl-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-yl)-2-phenoxy-acetamide (94103-31-8) + 4-nitro-benzoyl chloride (122-04-3) → 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem (132645-19-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo00006a035

Reference yield: 3.3%

methanol (67-56-1) + 3-methyl-4-<((p-nitrobenzoyl)oxy)methyl>-7β-(phenoxyacetamido)-3-cephem (132645-19-3) → 4-Nitro-benzoic acid (2S,3S,7R)-3-bromo-2-methoxy-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ylmethyl ester (99809-77-5,99828-79-2) + 4-Nitro-benzoic acid (2S,3R,7R)-3-bromo-2-methoxy-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ylmethyl ester + (4S,2'S)-3β-bromo-3-methyl-7β-(phenoxyacetamido)-4-spiro-4'-<2'-methoxy-2'-(p-nitrophenyl)-1',3'-dioxolane>cepham (132645-20-6,132746-29-3) + (4S,2'R)-3β-bromo-3-methyl-7β-(phenoxyacetamido)-4-spiro-4'-<2'-methoxy-2'-(p-nitrophenyl)-1',3'-dioxolane>cepham (132645-20-6,132746-29-3)

Guidance literature:

With bromine; calcium carbonate; at 0 ℃; for 0.5h; Product distribution;

DOI:10.1021/jo00006a035

upstream raw materials:

N-((R)-2-Hydroxymethyl-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-yl)-2-phenoxy-acetamide

4-nitro-benzoyl chloride

Downstream raw materials:

4-Nitro-benzoic acid (2S,3S,7R)-3-bromo-2-methoxy-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ylmethyl ester

(4S,2'S)-3β-bromo-3-methyl-7β-(phenoxyacetamido)-4-spiro-4'-<2'-methoxy-2'-(p-nitrophenyl)-1',3'-dioxolane>cepham

(4S,2'R)-3β-bromo-3-methyl-7β-(phenoxyacetamido)-4-spiro-4'-<2'-methoxy-2'-(p-nitrophenyl)-1',3'-dioxolane>cepham