6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one

Base Information

• Chemical Name: 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one
• CAS No.: 1352717-97-5
• Molecular Formula: C₁₇H₁₄FIN₂O₂
• Molecular Weight: 424.213
• Mol file: 1352717-97-5.mol

Synonyms:6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one

Chemical Property of 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one

There total 3 articles about 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

8-iodo-6-fluoro-2-methylquinazolin-4(3H)-one (1352717-93-1) + p-methoxybenzyl chloride (824-94-2) → 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one (1352717-97-5)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 24h;

DOI:10.1016/j.tet.2011.11.008

Reference yield:

2-amino-5-fluoro-3-iodobenzoic acid (331647-14-4) → 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one (1352717-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h / 140 °C

2: ammonia / water / 2 h / 100 °C

3: potassium carbonate / acetone / 24 h / 60 °C

With ammonia; potassium carbonate; In water; acetone;

DOI:10.1016/j.tet.2011.11.008

Reference yield:

2-amino-5-fluorobenzoic acid (446-08-2) → 6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one (1352717-97-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; Iodine monochloride / water / 48 h / 0 - 20 °C / Darkness

2: 2 h / 140 °C

3: ammonia / water / 2 h / 100 °C

4: potassium carbonate / acetone / 24 h / 60 °C

With hydrogenchloride; ammonia; Iodine monochloride; potassium carbonate; In water; acetone;

DOI:10.1016/j.tet.2011.11.008

upstream raw materials:

2-amino-5-fluoro-3-iodobenzoic acid

8-iodo-6-fluoro-2-methylquinazolin-4(3H)-one

p-methoxybenzyl chloride

2-amino-5-fluorobenzoic acid

Downstream raw materials:

6-fluoro-3-(4-methoxybenzyl)-2-methyl-8-morpholino-quinazolin-4(3H)-one

8-iodo-3-(4-methoxybenzyl)-2-methyl-6-morpholino-quinazolin-4(3H)-one

C₂₂H₂₄FN₃O₃

6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one