6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

Base Information

Chemical Name:6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one
CAS No.:1352717-99-7
Molecular Formula:C₂₂H₂₄IN₃O₃
Molecular Weight:505.355
Hs Code.:

Synonyms:6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

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Chemical Property of 6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

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Technology Process of 6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

There total 5 articles about 6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1352717-97-5
6-fluoro-8-iodo-3-(4-methoxybenzyl)-2-methyl-quinazolin-4(3H)-one

: 1352718-20-7
C₂₂H₂₄FN₃O₃

: 1352717-99-7
6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

Guidance literature:: at 140 ℃; for 72h;
DOI:10.1016/j.tet.2011.11.008

Reference yield:

: 331647-14-4
2-amino-5-fluoro-3-iodobenzoic acid

: 1352718-20-7
C₂₂H₂₄FN₃O₃

: 1352717-99-7
6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / 140 °C

2: ammonia / water / 2 h / 100 °C

3: potassium carbonate / acetone / 24 h / 60 °C

4: 72 h / 140 °C

With ammonia; potassium carbonate; In water; acetone;
DOI:10.1016/j.tet.2011.11.008

Reference yield:

: 446-08-2
2-amino-5-fluorobenzoic acid

: 1352718-20-7
C₂₂H₂₄FN₃O₃

: 1352717-99-7
6-(4-hydroxypiperidin-1-yl)-8-iodo-3-(4-methoxy-benzyl)-2-methylquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; Iodine monochloride / water / 48 h / 0 - 20 °C / Darkness

2: 2 h / 140 °C

3: ammonia / water / 2 h / 100 °C

4: potassium carbonate / acetone / 24 h / 60 °C

5: 72 h / 140 °C

With hydrogenchloride; ammonia; Iodine monochloride; potassium carbonate; In water; acetone;
DOI:10.1016/j.tet.2011.11.008