tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester

Base Information

• Chemical Name: tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester
• CAS No.: 1326394-37-9
• Molecular Formula: C₁₇H₂₅N₃O₄
• Molecular Weight: 335.403
• Mol file: 1326394-37-9.mol

Synonyms:tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester

Chemical Property of tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester

There total 4 articles about tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Nitrophenyl chloroformate (7693-46-1) + 4-fluoroaniline (371-40-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester (1326394-37-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.ejmech.2018.12.064

Reference yield: 88.0%

→ tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester (1326394-37-9)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

4-methoxy-aniline (104-94-9) + 1,1'-carbonyldiimidazole (530-62-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester (1326394-37-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 25 ℃;

DOI:10.1080/14756366.2021.1900163

upstream raw materials:

4-methoxy-aniline

4-Nitrophenyl chloroformate

4-fluoroaniline

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

piperazine-1-carboxylic acid (4-methoxy-phenyl)-amide

C₂₁H₃₂N₄O₂

C₂₃H₃₆N₄O₄