3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Base Information

Chemical Name:3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide
CAS No.:849670-38-8
Molecular Formula:C₂₃H₃₄FN₃O₃
Molecular Weight:419.54
Hs Code.:

Synonyms:3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Suppliers and Price of 3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

There total 3 articles about 3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 110-91-8,99108-56-2
morpholine

: 849671-45-0
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

: 849670-38-8
3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

Reference yield:

: 849671-44-9
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

: 849670-38-8
3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 8 h / 0 - 23 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane

With lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane;

Reference yield:

: 50622-51-0
N₁-(4-fluorophenyl)ethane-1,2-diamine

: 849670-38-8
3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 5 h

2: lithium hydroxide; water / methanol / 8 h / 0 - 23 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane

With lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane;