(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

Base Information

Chemical Name:(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester
CAS No.:849671-44-9
Molecular Formula:C₂₀H₂₉FN₂O₃
Molecular Weight:364.46
Hs Code.:

Synonyms:(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

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Chemical Property of (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

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Technology Process of (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

There total 1 articles about (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 50622-51-0
N₁-(4-fluorophenyl)ethane-1,2-diamine

: 130165-88-7
(R)-2-(Cyclohexylmethyl)-succinic acid 1-methyl ester

: 849671-44-9
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 5h;

Reference yield: 86.0%

: 849671-44-9
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

: 849671-45-0
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

Guidance literature:: With lithium hydroxide; water; In methanol; at 0 - 23 ℃; for 8h;

Reference yield:

: 849671-44-9
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

: 849670-38-8
3-(R)-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / methanol / 8 h / 0 - 23 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane

With lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane;