(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

Base Information

Chemical Name:(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid
CAS No.:849671-45-0
Molecular Formula:C₁₉H₂₇FN₂O₃
Molecular Weight:350.433
Hs Code.:

Synonyms:(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

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Chemical Property of (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

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Technology Process of (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

There total 2 articles about (R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 849671-44-9
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid methyl ester

: 849671-45-0
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

Guidance literature:: With lithium hydroxide; water; In methanol; at 0 - 23 ℃; for 8h;

Reference yield:

: 50622-51-0
N₁-(4-fluorophenyl)ethane-1,2-diamine

: 849671-45-0
(R)-2-cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 5 h

2: lithium hydroxide; water / methanol / 8 h / 0 - 23 °C

With lithium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane;