4-o-methylbenzenesulfonyloxy benzoxazolone

Base Information

• Chemical Name: 4-o-methylbenzenesulfonyloxy benzoxazolone
• CAS No.: 1082928-52-6
• Molecular Formula: C₁₄H₁₁NO₅S
• Molecular Weight: 305.311
• Mol file: 1082928-52-6.mol

Synonyms:4-o-methylbenzenesulfonyloxy benzoxazolone

Chemical Property of 4-o-methylbenzenesulfonyloxy benzoxazolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-o-methylbenzenesulfonyloxy benzoxazolone

There total 2 articles about 4-o-methylbenzenesulfonyloxy benzoxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Toluene-2-sulfonyl chloride (133-59-5) + 4-hydroxybenzo[d]oxazol2(3H)-one (28955-70-6) → 4-o-methylbenzenesulfonyloxy benzoxazolone (1082928-52-6)

Guidance literature:

With triethylamine; In acetone; for 0.5h; Cooling with ice; Reflux;

DOI:10.1016/j.bmcl.2013.02.048

Reference yield:

2-aminoresorcinol (3163-15-3) → 4-o-methylbenzenesulfonyloxy benzoxazolone (1082928-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / Inert atmosphere; Reflux

2: triethylamine / acetone / 0.5 h / Cooling with ice; Reflux

With triethylamine; In tetrahydrofuran; acetone;

DOI:10.1016/j.bmcl.2013.02.048

Reference yield: 75.0%

4-o-methylbenzenesulfonyloxy benzoxazolone (1082928-52-6) + benzyl bromide (100-39-0) → N-benzyl-4-(2-methyl-benzenesulfonyl)-2-benzoxazolone

Guidance literature:

4-o-methylbenzenesulfonyloxy benzoxazolone; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

benzyl bromide; In acetone; Reflux;

DOI:10.1016/j.bmc.2020.115733

upstream raw materials:

2-aminoresorcinol

Toluene-2-sulfonyl chloride

4-hydroxybenzo[d]oxazol2(3H)-one