3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel-

Base Information

Chemical Name:3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel-
CAS No.:302959-28-0
Molecular Formula:C₁₆H₁₈FNO*ClH
Molecular Weight:295.784
Hs Code.:

Synonyms:3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride, (2R,3S)-rel- (9CI)

Suppliers and Price of 3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s): A poison.
Hazard Codes: A poison.:;
Safety Statements:A poison by subcutaneous route. When heated to decomposition it emits toxic va"> x, HCl, Cl−, and F−." target="_blank">A poison by subcutaneous route. When heated to decomposition it emits toxic va

MSDS Files:

Useful:

Technology Process of 3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel-

There total 3 articles about 3-Pyrrolidinol,3-(6-fluoro-2-naphthalenyl)-1,2-dimethyl-, hydrochloride (1:1), (2R,3S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.1%

: 89531-03-3
(R,S)-1,2-dimethyl-3-pyrrolidone

: 324-41-4
2-bromo-6-fluoronaphthalene

: 302959-28-0
(2RS,3SR)-1,2-dimethyl-3-[2-(6-fluoronaphthyl)-3-hydroxy]pyrrolidine hydrochloride

Guidance literature:: 2-bromo-6-fluoronaphthalene; With tert.-butyl lithium; In diethyl ether; pentane; at -40 - -5 ℃;

(R,S)-1,2-dimethyl-3-pyrrolidone; In diethyl ether; at -5 ℃; for 3h;

With hydrogenchloride; for 0.25h; pH=2;
DOI:10.1016/S0968-0896(00)00117-6

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 302959-28-0
(2RS,3SR)-1,2-dimethyl-3-[2-(6-fluoronaphthyl)-3-hydroxy]pyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 30 percent NH₄OH; ammonium sulfite / 27 h / 150 °C

2.1: 50 percent NaNO₂; 3.5 percent HCl; 60 percent hexafluorophosphoric acid / 0 °C

3.1: t-BuLi / pentane; diethyl ether / -40 - -5 °C

3.2: diethyl ether / 3 h / -5 °C

3.3: 44.1 percent / 10 percent HCl / 0.25 h / pH 2

With hydrogenchloride; ammonium hydroxide; hexafluorophosphoric acid; ammonium sulfite; tert.-butyl lithium; sodium nitrite; In diethyl ether; pentane; 1.1: Substitution / 2.1: Diazotization / 2.2: Decomposition / 3.1: Metallation / 3.2: Substitution / 3.3: salt formation;
DOI:10.1016/S0968-0896(00)00117-6

Reference yield:

: 7499-66-3
6-Bromonaphthalen-2-amine

: 302959-28-0
(2RS,3SR)-1,2-dimethyl-3-[2-(6-fluoronaphthyl)-3-hydroxy]pyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 50 percent NaNO₂; 3.5 percent HCl; 60 percent hexafluorophosphoric acid / 0 °C

2.1: t-BuLi / pentane; diethyl ether / -40 - -5 °C

2.2: diethyl ether / 3 h / -5 °C

2.3: 44.1 percent / 10 percent HCl / 0.25 h / pH 2

With hydrogenchloride; hexafluorophosphoric acid; tert.-butyl lithium; sodium nitrite; In diethyl ether; pentane; 1.1: Diazotization / 1.2: Decomposition / 2.1: Metallation / 2.2: Substitution / 2.3: salt formation;
DOI:10.1016/S0968-0896(00)00117-6