{(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester
• CAS No.: 209796-51-0
• Molecular Formula: C₂₅H₄₁N₃O₇S
• Molecular Weight: 527.682

Synonyms:{(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

Chemical Property of {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

There total 10 articles about {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9) + [(methoxy-methyl-carbamoyl)-(4-oxo-cyclohexyl)-methyl]-carbamic acid tert-butyl ester (209796-49-6) → {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester (209796-51-0) + {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

Guidance literature:

[(methoxy-methyl-carbamoyl)-(4-oxo-cyclohexyl)-methyl]-carbamic acid tert-butyl ester; With ammonium acetate; 4 A molecular sieve; sodium cyanoborohydride; In isopropyl alcohol;

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(00)00636-3

Reference yield:

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9) → {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester (209796-51-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2,2-dimethoxypropane; HCl / methanol; dioxane / 18 h

1.2: Et₃N / CH₂Cl₂ / 4 h / 0 - 20 °C

1.3: 58 percent / methanol / 18 h / Heating

2.1: 67 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3.1: 51 percent / Dess-Martin periodinane / CH₂Cl₂ / 18 h

4.1: 34 percent / ethanol; H₂O / 5 h / Heating

5.1: aq. NaOH / 18 h / Heating

5.2: 81 percent / 18 h / 0 - 20 °C

6.1: Et₃N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 4 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; Dess-Martin periodane; triethylamine; 2,2-dimethoxy-propane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 3.1: Dess-Martin oxidation / 4.1: Strecker reaction;

DOI:10.1021/jm0303857

Reference yield:

N-(4-formyl-cyclohexyl)-4-methoxy-2,3,6-trimethyl-benzenesulfonamide (804547-82-8) → {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester (209796-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 34 percent / ethanol; H₂O / 5 h / Heating

2.1: aq. NaOH / 18 h / Heating

2.2: 81 percent / 18 h / 0 - 20 °C

3.1: Et₃N; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 4 h

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In ethanol; dichloromethane; water; 1.1: Strecker reaction;

DOI:10.1021/jm0303857

upstream raw materials:

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

[(methoxy-methyl-carbamoyl)-(4-oxo-cyclohexyl)-methyl]-carbamic acid tert-butyl ester

(S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

{1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester

[1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

{2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

(6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 209796-51-0 {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send