Technology Process of 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-2,3,7,7a,8,9,10,11-octahydro-1H-pyrrolo[2,1-j]quinolin-6-yl]-ethanone
There total 10 articles about 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-2,3,7,7a,8,9,10,11-octahydro-1H-pyrrolo[2,1-j]quinolin-6-yl]-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[4-(tert-butyl-diphenyl-silanyloxy)-3-(3-oxo-but-1-enylamino)-butyl]-cyclohex-1-enecarbaldehyde;
With
piperdinium acetate; sodium sulfate;
In
ethyl acetate;
for 12h;
Heating;
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 4h;
under 760 Torr;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: aq. K3PO4 / PdCl2(dppf)*CH2Cl2 / tetrahydrofuran / 12 h / Heating
2.1: pyridinium p-toluenesulfonate / methanol / 1 h / Heating
3.1: imidazole / CH2Cl2 / 20 °C
4.1: 12.0 g / DIBAL-H / CH2Cl2 / -78 - 0 °C
5.1: pyridine / 20 °C
6.1: 100 percent / TFA / CH2Cl2 / 1 h / 0 °C
7.1: CH2Cl2 / 40 °C
8.1: K2CO3 / methanol; H2O / 1 h / 20 °C
9.1: N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 20 °C
10.1: piperidinium acetate; Na2SO4 / ethyl acetate / 12 h / Heating
10.2: 50.0 mg / H2 / 10 percent Pd/C / ethyl acetate / 4 h / 760 Torr
With
pyridine; 1H-imidazole; potassium phosphate; tetrapropylammonium perruthennate; 4 A molecular sieve; pyridinium p-toluenesulfonate; piperdinium acetate; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; sodium sulfate; trifluoroacetic acid;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
1.1: Suzuki-Miyaura coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: CH2Cl2 / 40 °C
2.1: K2CO3 / methanol; H2O / 1 h / 20 °C
3.1: N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 20 °C
4.1: piperidinium acetate; Na2SO4 / ethyl acetate / 12 h / Heating
4.2: 50.0 mg / H2 / 10 percent Pd/C / ethyl acetate / 4 h / 760 Torr
With
tetrapropylammonium perruthennate; 4 A molecular sieve; piperdinium acetate; potassium carbonate; 4-methylmorpholine N-oxide; sodium sulfate;
In
methanol; dichloromethane; water; ethyl acetate;
![2-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-3-(3-oxo-but-1-enylamino)-butyl]-cyclohex-1-enecarbaldehyde](/Databaselist/images/loading.webp)
