methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

Base Information

Chemical Name:methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate
CAS No.:1372589-69-9
Molecular Formula:C₁₉H₂₂ClN₃O₄
Molecular Weight:391.854
Hs Code.:

Synonyms:methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

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Chemical Property of methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

Chemical Property:

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Technology Process of methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

There total 6 articles about methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372589-68-8
methyl 2-(5-(tert-butoxycarbonylamino)-2-nitrophenylamino)-4-chlorobenzoate

: 1372589-69-9
methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

Guidance literature:: With hydrogen; Raney Ni; In tetrahydrofuran; methanol; at 20 ℃; for 3h; under 1551.49 Torr;

Reference yield:

: 2-amino-4-(N-tert-butoxycarbonylamino)nitrobenzene

: 1372589-69-9
methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

With hydrogen; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; toluene; 1: Buchwald-Hartwig amination;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1372589-69-9
methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -10 °C

1.2: 18 h / -10 - 20 °C

2.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

3.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

With hydrogen; potassium hexamethylsilazane; caesium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; toluene; 2.1: Buchwald-Hartwig amination;