3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Base Information

• Chemical Name: 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid
• CAS No.: 111194-04-8
• Molecular Formula: C₁₃H₁₆O₆
• Molecular Weight: 268.266
• Mol file: 111194-04-8.mol

Synonyms:3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Chemical Property of 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid

There total 4 articles about 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester (122977-46-2) → 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid (111194-04-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.3987/R-1987-05-1169

Reference yield:

acide (benzyloxy-4 methoxy-3 phenyl)-4 methoxycarbonyl-3 butene-3 oique (84755-39-5) → 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid (111194-04-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; under 760 Torr; Ambient temperature;

DOI:10.1071/CH9822175

Reference yield:

vanillin (121-33-5,8014-42-4) → 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid (111194-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / lithium methoxide / methanol

2: 85 percent / H₂ / Pd/C / acetic acid

With lithium methanolate; hydrogen; palladium on activated charcoal; In methanol; acetic acid;

DOI:10.3987/R-1987-05-1169

upstream raw materials:

2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester

acide (benzyloxy-4 methoxy-3 phenyl)-4 methoxycarbonyl-3 butene-3 oique

vanillin

Dimethyl succinate

Downstream raw materials:

4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-benzyloxy-3-methoxy-benzyl)-dihydro-furan-2-one

4-[Benzyloxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-3-(4-hydroxy-3-methoxy-benzyl)-dihydro-furan-2-one

(+/-)-α-conidendrin

(+/-)-3-(α-Benzyloxy-4-trimethylsiloxy-3-methoxybenzyl)butan-4-olide