thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester

Base Information

• Chemical Name: thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester
• CAS No.: 909020-07-1
• Molecular Formula: C₁₃H₁₅FN₂O₃S
• Molecular Weight: 298.338

Synonyms:thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester

Chemical Property of thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester

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Technology Process of thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester

There total 4 articles about thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-Bromomethyl-1-(2-fluoro-4-nitro-phenyl)-pyrrolidine (909020-06-0) + tiolacetic acid (507-09-5) → thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester (909020-07-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 8 ℃;

DOI:10.1016/j.bmcl.2006.05.071

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester (909020-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Hunig's base / acetonitrile / 5 h / 20 °C

2: 93 percent / CBr₄; PPh₃ / CH₂Cl₂ / 5 h / 0 - 45 °C

3: 100 percent / NaH / tetrahydrofuran / 8 °C

With carbon tetrabromide; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.05.071

Reference yield:

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → thioacetic acid S-[1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl] ester (909020-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Hunig's base / acetonitrile / 5 h / 20 °C

2: 93 percent / CBr₄; PPh₃ / CH₂Cl₂ / 5 h / 0 - 45 °C

3: 100 percent / NaH / tetrahydrofuran / 8 °C

With carbon tetrabromide; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.05.071

upstream raw materials:

(S)-2-Bromomethyl-1-(2-fluoro-4-nitro-phenyl)-pyrrolidine

tiolacetic acid

3,4-difluoronitrobenzene

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

(2,3,3a,4-tetrahydro-1H-5-thia-9b-aza-cyclopenta[a]naphthalen-7-yl)-carbamic acid benzyl ester

[(S)-1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-yl]-methanethiol

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