9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol

Base Information

• Chemical Name: 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol
• CAS No.: 135643-71-9
• Molecular Formula: C₁₉H₃₃NO₈S
• Molecular Weight: 435.539
• Mol file: 135643-71-9.mol

Synonyms:9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol

Chemical Property of 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol

There total 3 articles about 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) + toluene-4-sulfonamide (70-55-3) → 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol (135643-71-9,63413-83-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 96h;

DOI:10.1016/S0040-4020(99)00573-6

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol (135643-71-9,63413-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; triethylamine; In dichloromethane;

Reference yield:

toluene-4-sulfonamide (70-55-3) + 8-tosyloxy-3,6-dioxaoctanol (77544-68-4) → N-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethyl}-4-methyl-benzenesulfonamide (135643-72-0) + 9-[(4-methylphenyl)sulfonyl]-3,6,12,15-tetraoxa-9-aza-1,17-heptadecanediol (135643-71-9,63413-83-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

upstream raw materials:

toluene-4-sulfonamide

8-tosyloxy-3,6-dioxaoctanol

2-[2-(chloroethoxy)ethoxy]ethanol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

7,16-bis(p-tolylsulphonyl)-1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

3,6,12,15-tetraoxa-9-azaheptadecane-1,17-diol

4-benzyl-13-[(4-methylphenyl)sulfonyl]-1,7,10,16-tetraoxa-4,13-diazacyclooctadecane