(3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE

Base Information

Chemical Name:(3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE
CAS No.:205442-89-3
Molecular Formula:C18H18 N4 O
Molecular Weight:306.367
Hs Code.:
Mol file:205442-89-3.mol

Synonyms:1H-Benzotriazole,1-(hexahydro-3-phenylpyrrolo[2,1-b]oxazol-5-yl)-, [3S-(3a,5a,7aa)]-

Suppliers and Price of (3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of (3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE

Chemical Property:

PSA：43.18000
LogP:3.06120

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE

There total 5 articles about (3S,5R,7AR)-5-(BENZOTRIAZOL-1-YL)-3-PHENYL[2,1-B]OXAZOLOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 20989-17-7
(2S)-2-phenylglycinol

: 205442-89-3
(3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl<2,1-b>oxazolopyrrolidine

Guidance literature:: cis,trans-2,5-dimethoxytetrahydrofuran; With hydrogenchloride; In water; for 1h; Heating / reflux;

1,2,3-Benzotriazole; (2S)-2-phenylglycinol; In dichloromethane; water; at 20 ℃;

Reference yield:

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 20989-17-7
(2S)-2-phenylglycinol

: 2592-95-2
benzotriazol-1-ol

: 205442-89-3
(3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl<2,1-b>oxazolopyrrolidine

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2013.03.092

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 205442-89-3
(3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl<2,1-b>oxazolopyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Reflux

2: hydrogenchloride / water / 12 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.03.092