N-CYCLOHEXYL-N'-(2-HYDROXYETHYL)UREA

Base Information

• Chemical Name: N-CYCLOHEXYL-N'-(2-HYDROXYETHYL)UREA
• CAS No.: 66929-46-2
• Molecular Formula: C9H18 N2 O2
• Molecular Weight: 186.254
• Hs Code.: 2924299090
• Mol file: 66929-46-2.mol

Synonyms:Urea,1-cyclohexyl-3-(2-hydroxyethyl)- (6CI); 3-Cyclohexyl-1-(2-hydroxyethyl)urea;N-Cyclohexyl-N'-(2-hydroxyethyl)urea

Chemical Property of N-CYCLOHEXYL-N'-(2-HYDROXYETHYL)UREA

Chemical Property:

• PSA: 64.85000
• LogP: 1.20590

Purity/Quality:

98%min ^*data from raw suppliers

1-CYCLOHEXYL-3-(2-HYDROXYETHYL)UREA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CYCLOHEXYL-N'-(2-HYDROXYETHYL)UREA

There total 4 articles about N-CYCLOHEXYL-N'-(2-HYDROXYETHYL)UREA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethanolamine (141-43-5) + Cyclohexyl isocyanate (3173-53-3) → 3-cyclohexyl-1-(2-hydroxyethyl) urea (66929-46-2)

Guidance literature:

In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/jm00135a007

Reference yield:

2-(cyclohexylimino)-3-nitroso-2-oxazolidine (76310-06-0) → dimethylenecyclourethane (497-25-6) + 2-(cyclohexylamino)-2-oxazoline (10002-37-6) + 2-hydroxyethyl N-cyclohexylcarbamate (13027-13-9) + 3-cyclohexyl-1-(2-hydroxyethyl) urea (66929-46-2) + acetaldehyde (75-07-0,9002-91-9) + 1,3-Dicyclohexylurea (2387-23-7)

Guidance literature:

With phosphate buffer; at 37 ℃; for 12h; Product distribution; other 2-(alkylimino)-3-nitroso-2-oxazolidines; also decomp. of 3-cyclohexyl-1-(2-hydroxyethyl)-1-nitrosourea; also in NaCl sat. sol.; pH 7.2;

DOI:10.1021/jm00135a007

Reference yield:

N3-cyclohexyl-N1-(2-hydroxyethyl)-N1-nitrosothiourea (84056-92-8) → 2-(cyclohexylamino)-2-oxazoline (10002-37-6) + 2-hydroxyethyl N-cyclohexylcarbamate (13027-13-9) + 3-cyclohexyl-1-(2-hydroxyethyl) urea (66929-46-2) + 2-hydroxyethyl-N-cyclohexylthionocarbamate (87191-82-0)

Guidance literature:

With potassium phosphate buffer; at 37 ℃; for 12h; Further byproducts given;

DOI:10.1021/jo00170a006

upstream raw materials:

2-(cyclohexylimino)-3-nitroso-2-oxazolidine

N₃-cyclohexyl-N₁-(2-hydroxyethyl)-N₁-nitrosothiourea

ethanolamine

Cyclohexyl isocyanate

Downstream raw materials:

3-cyclohexyl-1-(2-hydroxyethyl)-1-nitrosourea

Refernces

• 1、 Lown,Chauhan. "Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea". . p. 270 - 279. Retrieved 2007/10/02.