N-(4-METHOXYPHENYL)PROPIONAMIDE

Base Information

• Chemical Name: N-(4-METHOXYPHENYL)PROPIONAMIDE
• CAS No.: 2760-31-8
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 2760-31-8.mol

Synonyms:p-Propionanisidide(7CI,8CI);4-Methoxypropionanilide;4'-Methoxypropionanilide;N-(4-Methoxyphenyl)propanamide;N-(4-Methoxyphenyl)propionamide;N-(4-methoxyphenyl)propanamide;N-(4-Methoxyphenyl)propanamide;propanamide, N-(4-methoxyphenyl)-;

Chemical Property of N-(4-METHOXYPHENYL)PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 3.21E-05mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 355.1 °C at 760 mmHg
• Flash Point: 168.5 °C
• PSA: 38.33000
• Density: 1.099 g/cm³
• LogP: 2.11670

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-methoxyphenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-METHOXYPHENYL)PROPIONAMIDE

There total 15 articles about N-(4-METHOXYPHENYL)PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxy-aniline (104-94-9) + propionic acid (802294-64-0,79-09-4) → N-(4-methoxyphenyl)-propanamide (2760-31-8)

Guidance literature:

propionic acid; With diatomite earth(at)IL/ZrCl₄ (Lewis acidic ionic liquid immobilized on diatomite earth); In toluene; for 0.0833333h; Green chemistry;

4-methoxy-aniline; In toluene; at 20 ℃; for 0.333333h; Sonication; Green chemistry;

DOI:10.1007/s11164-018-3592-9

Reference yield: 93.0%

4-methoxy-aniline (104-94-9) + Propionamid (79-05-0) → N-(4-methoxyphenyl)-propanamide (2760-31-8)

Guidance literature:

at 150 ℃; for 24h; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.8b03542

Reference yield: 92.0%

4-methoxy-aniline (104-94-9) + 3,5-heptanedione (7424-54-6) → N-(4-methoxyphenyl)-propanamide (2760-31-8)

Guidance literature:

With dihydrogen peroxide; In water; at 25 ℃; for 8h; Green chemistry;

DOI:10.1039/c3gc41260a

upstream raw materials:

4-methoxy-aniline

propionic acid

1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one

Ethyl propionate

Downstream raw materials:

2-Chloro-6-methoxy-3-methylquinoline

N-(4-methoxyphenyl)-N-propylamine

1-(4-methoxyphenyl)-4-phenyl-1H-quinolin-2-one

2-ethyl-6-methoxy-benzothiazole

Refernces

• 1、 Mugnaini, Claudia,Brizzi, Antonella,Mostallino, Rafaela,Castelli, Maria Paola,Corelli, Federico. "Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators". . . Retrieved 2020/08/06.
• 2、 Wang, Shi-Meng,Zhao, Chuang,Zhang, Xu,Qin, Hua-Li. "Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages". . p. 4087 - 4101. Retrieved 2019/04/30.