AOA acetate

Base Information

• Chemical Name: AOA acetate
• CAS No.: 188923-21-9
• Molecular Formula: C9H19NO5
• Molecular Weight: 221.25
• Mol file: 188923-21-9.mol

Synonyms:AOA ACETATE

Chemical Property of AOA acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AOA acetate

There total 6 articles about AOA acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ (5R,6S)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol acetate (188923-21-9)

Guidance literature:

Reference yield: 90.0%

acetic acid (64-19-7,77671-22-8) + (5R,6S)-2,2-dimethyl-6-[(R)-1-phenylethylamino]-1,3-dioxepan-5-ol (188923-19-5) → (5R,6S)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol acetate (188923-21-9)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jo981472n

Reference yield:

acetic acid (64-19-7,77671-22-8) + (5R,6S)-2,2-dimethyl-6-(1-phenylmethylamino)-1,3-dioxepan-5-ol → (5R,6S)-2,2-dimethyl-5-hydroxy-1,3-dioxepan-6-ylammonium acetate (188923-21-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In isopropyl alcohol; for 24h; under 2280 Torr; Yield given; Ambient temperature;

DOI:10.1021/jo9900883

upstream raw materials:

acetic acid

(5R,6S)-2,2-dimethyl-6-[(R)-1-phenylethylamino]-1,3-dioxepan-5-ol

2,2-dimethyl-4,7-dihydro-1,3-dioxepin

4,4-dimethyl-3,5,8-trioxa-bicyclo-[5.1.0]octane

Refernces

• 1、 -. "Production of amide derivatives and intermediate compounds therefor". . . Retrieved 2008/06/13.
• 2、 Inaba, Takashi,Birchler, Angela G.,Yamada, Yasuki,Sagawa, Shoichi,Yokota, Katsuyuki,Ando, Koji,Uchida, Itsuo. "A Practical Synthesis of Nelfinavir, an HIV-Protease Inhibitor, Using a Novel Chiral C4 Building Block: (5R,6S)-2,2-Dimethyl-5-hydroxy-l,3-dioxepan-6-ylammonium Acetate". . p. 7582 - 7583. Retrieved 2007/10/03.