(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Base Information

Chemical Name:(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine
CAS No.:466651-80-9
Molecular Formula:C₂₇H₄₄N₄O₇S₃Si
Molecular Weight:660.952
Hs Code.:

(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Synonyms:(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

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Chemical Property of (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

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Technology Process of (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

There total 2 articles about (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.1%

: 123-90-0
Thiomorpholin

: 466651-79-6
(2S,4R)-2-[3-(2-chloroethanesulfonyl)thiazolidin-2-yl]-4-(tert-butyldimethylsilanyloxy)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

: 466651-80-9
(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 10h;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B

Reference yield:

: 137049-21-9
(2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 466651-80-9
(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 87.2 percent / NaHCO₃ / ethanol; H₂O / 24 h / 20 °C

2: 76.9 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 80.1 percent / K₂CO₃ / dimethylformamide / 10 h / 90 °C

With sodium hydrogencarbonate; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 466651-80-9
(4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

: (2S,4R)-4-Methanesulfonyloxy-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)-thiazolidin-2-yl]-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[3-(2-thiomorpholin-4-yl-ethanesulfonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/1521-4184(200204)335:4<152::AID-ARDP152>3.0.CO;2-B