methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate

Base Information

• Chemical Name: methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate
• CAS No.: 223437-55-6
• Molecular Formula: C₁₈H₂₁Cl₂N₃O₃
• Molecular Weight: 398.289
• Mol file: 223437-55-6.mol

Synonyms:methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate

Chemical Property of methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate

There total 1 articles about methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate (72083-62-6) + 4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride (15944-88-4) → methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate (223437-55-6)

Guidance literature:

With TEA; In 1,4-dioxane; Ambient temperature;

DOI:10.1016/S0968-0896(98)00205-3

Reference yield: 76.0%

methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate (223437-55-6) → 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylic acid (177409-18-6)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1016/S0968-0896(98)00205-3

Reference yield:

methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate (223437-55-6) → 5-[(4-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-methyl-1H-pyrrole-2-carbonyl)-amino]-2-methyl-2H-pyrazole-3-carboxylic acid [5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-amide; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / aq. KOH / dioxane / 2 h / Ambient temperature

2: DIPEA, EDC / dimethylformamide / 18 h / Ambient temperature

With potassium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(98)00205-3

upstream raw materials:

methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride

Downstream raw materials:

1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylic acid