methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

Base Information

Chemical Name:methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate
CAS No.:1256779-90-4
Molecular Formula:C₃₆H₄₃N₃O₄
Molecular Weight:581.755
Hs Code.:

Synonyms:methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

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Chemical Property of methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

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Technology Process of methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

There total 6 articles about methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 1256779-89-1
6-butyl-5-(4-hydroxy-3,5-dipropylbenzyl)-2-methyl-3-(pyridin-2-yl)pyrimidin-4(3H)-one

: 1256779-90-4
methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256779-90-4
methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 12 h / Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

6.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With ammonium acetate; tetrabutyl ammonium fluoride; trimethylaluminum; phosphorus tribromide; sodium hydride; caesium carbonate; acetic acid; In tetrahydrofuran; n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 161922-06-1
4-(bromomethyl-2,6-diisopropylphenoxy)(tert-butyl)dimethylsilane

: 1256779-90-4
methyl 2-[4-[{4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl}methyl]-2,6-dipropylphenoxy]-2-phenyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

2.2: 14 h / 70 °C

3.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

3.2: 12 h / Reflux

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / cooling with ice

5.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With ammonium acetate; tetrabutyl ammonium fluoride; trimethylaluminum; sodium hydride; caesium carbonate; acetic acid; In tetrahydrofuran; n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;